Dp(16Ifnar1-Kcnj6)10Yey
Targeted Allele Detail

Summary

• Symbol: Dp(16Ifnar1-Kcnj6)10Yey
• Name: duplication, Chr 16, Y Eugene Yu 10
• MGI ID: MGI:5561090
• Synonyms: Dp(16)10Yey, Dp(16)4Yey, Dp(16Ifnar1-Kcnj6)4Yey, Ts6Yey
• Gene: Dp(16Ifnar1-Kcnj6)10Yey Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208104
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutations: Duplication, Insertion
• Dp(16Ifnar1-Kcnj6)10Yey involves 87 genes/genome features (Gm22344, Gm23062, Gm22745 ...) View all
• Mutation details: This duplication was generated by recombination between two MICER clone insertions (MHPn247l16 and MHPP54c08). The 3.7 Mb duplication spans Ifnar1 to Kcnj6, which contains 17 Hsa21 gene orthologs. The duplication retains the puromycin and neomycin resistance cassettes from the original MICER clones. (J:208104)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(16Ifnar1-Kcnj6)10Yey Mutation: 1 strain or line available

References

• Original: J:208104 Liu C, et al., Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice. Hum Genet. 2014 Jun;133(6):743-53
• All: 1 reference(s)