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Kmt2atm2.1Mlc
Targeted Allele Detail
Summary
Symbol: Kmt2atm2.1Mlc
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 2.1, Michael L Cleary
MGI ID: MGI:5561120
Synonyms: MLLde, MLL deltaexon11
Gene: Kmt2a  Location: Chr9:44714652-44792594 bp, - strand  Genetic Position: Chr9, 24.84 cM
Alliance: Kmt2atm2.1Mlc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207555
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exon 11. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed very low or undetectable protein expression in mouse embryonic fibroblasts. (J:207555)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  135 strains or lines available
References
Original:  J:207555 Yokoyama A, et al., MLL becomes functional through intra-molecular interaction not by proteolytic processing. PLoS One. 2013;8(9):e73649
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory