Kmt2a^tm3Mlc
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm3Mlc
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 3, Michael L Cleary
• MGI ID: MGI:5561122
• Synonyms: MLL^uc
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm3Mlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207555
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions modified the first and second processing site (D2666A and D2718A) creating an uncleavable product. (J:207555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:207555 Yokoyama A, et al., MLL becomes functional through intra-molecular interaction not by proteolytic processing. PLoS One. 2013;8(9):e73649
• All: 1 reference(s)