Oprm1^tm1.1Cgrf
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1.1Cgrf
• Name: opioid receptor, mu 1; targeted mutation 1.1, Claire Gaveriaux-Ruff
• MGI ID: MGI:5561219
• Synonyms: Oprm1^fl
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1.1Cgrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207536
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed hygromycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:207536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:207536 Weibel R, et al., Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS One. 2013;8(9):e74706
• All: 19 reference(s)