Tg(Hcn4-cre/ERT2)1Yzhao
Transgene Detail

Summary

• Symbol: Tg(Hcn4-cre/ERT2)1Yzhao
• Name: transgene insertion 1, Yong Zhao
• MGI ID: MGI:5562295
• Synonyms: Hcn4-CreERT2
• Transgene: Tg(Hcn4-cre/ERT2)1Yzhao Location: unknown
• Alliance: Tg(Hcn4-cre/ERT2)1Yzhao page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Hcn4-cre/ERT2)1Yzhao expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Hcn4

• Mutation details: Recombineering methods were used to insert a cre/ERT2 cassette immediately after the ATG start codon of the Hcn4 locus in a bacterial artificial chromosome (this BAC does not encode other proteins or micro RNAs). The BAC construct was purified and used for pronuclear injection of fertilized oocytes. Two founders were generated, with essentially identical cre activity patterns following tamoxifen treatment being observed. One line was chosen for detailed analyses. (J:207828)

Generation of Tg(Hcn4-cre/ERT2)1Yzhao.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hcn4 (species not specified) Summary of all recombinase alleles driven by Hcn4. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:207828 Wu M, et al., Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice. Genesis. 2014 Feb;52(2):134-40
• All: 3 reference(s)