Gria1^tm7Rlh
Targeted Allele Detail

Summary

• Symbol: Gria1^tm7Rlh
• Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 7, Richard L Huganir
• MGI ID: MGI:5562310
• Synonyms: GluA1DD, GluA1 S831D/S845D
• Gene: Gria1 Location: Chr11:56902342-57221070 bp, + strand Genetic Position: Chr11, 34.51 cM
• Alliance: Gria1^tm7Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172128
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: S831D (TCC to GAT) and S845D (AGC to GAC) serine to aspartate mutations were introduced to GluA1 (Gria1) cDNA using QuikChange site-directed mutagenesis (Stratagene). (J:172128)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria1 Mutation: 65 strains or lines available

References

• Original: J:172128 Makino Y, et al., Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8450-5
• All: 1 reference(s)