Jak2^m1Dlbr
Chemically induced Allele Detail

Summary

• Symbol: Jak2^m1Dlbr
• Name: Janus kinase 2; mutation 1, Dwayne L Barber
• MGI ID: MGI:5562422
• Synonyms: Jak2^K915X
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^m1Dlbr page

Mutation origin

• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a A to T point mutation that results in the amino acid substitution of a stop codon for lysine at position 915 (K915X). Western blot analysis confirmed expression of a truncated protein in splenocytes. (J:207740)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:207740 Anderson NM, et al., Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PLoS One. 2013;8(9):e75472
• All: 1 reference(s)