Wwc1^tm1.1Arsc
Targeted Allele Detail

Summary

• Symbol: Wwc1^tm1.1Arsc
• Name: WW, C2 and coiled-coil domain containing 1; targeted mutation 1.1, Armin Schneider
• MGI ID: MGI:5562434
• Gene: Wwc1 Location: Chr11:35729227-35871354 bp, - strand Genetic Position: Chr11, 21.96 cM
• Alliance: Wwc1^tm1.1Arsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207867
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 15. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 15. Cre-mediated recombination removed exon 15 and the selection cassette. Western blot analysis confirmed the absence of protein expression. (J:207867)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwc1 Mutation: 55 strains or lines available

Notes

ES cells = CV19 (129Sv x C57BL/6J)

References

• Original: J:207867 Vogt-Eisele A, et al., KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mzeta. J Neurochem. 2014 Mar;128(5):686-700
• All: 1 reference(s)