Cadps^tm1.2Tfr
Targeted Allele Detail

Summary

• Symbol: Cadps^tm1.2Tfr
• Name: Ca2+-dependent secretion activator; targeted mutation 1.2, Teiichi Furuichi
• MGI ID: MGI:5562542
• Synonyms: Caps-
• Gene: Cadps Location: Chr14:9646684-10097200 bp, + strand Genetic Position: Chr14, 6.37 cM, cytoband A2
• Alliance: Cadps^tm1.2Tfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204664
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6 and an FRT-flanked neo cassette followed by another loxP site were inserted downstream of exon 6. The loxP-flanked exon 6 and neo cassette were removed by recombination. (J:204664)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadps Mutation: 70 strains or lines available

References

• Original: J:204664 Sadakata T, et al., CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J Neurosci. 2013 Oct 30;33(44):17326-34
• All: 2 reference(s)