Dab2^tm2.2Xxx
Targeted Allele Detail

Summary

• Symbol: Dab2^tm2.2Xxx
• Name: disabled 2, mitogen-responsive phosphoprotein; targeted mutation 2.2, Xiang-Xi Xu
• MGI ID: MGI:5562564
• Synonyms: dab2-
• Gene: Dab2 Location: Chr15:6329269-6470193 bp, + strand Genetic Position: Chr15, 2.15 cM, cytoband A2
• Alliance: Dab2^tm2.2Xxx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205046
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 3 and 4. (J:205046)

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab2 Mutation: 53 strains or lines available

References

• Original: J:205046 Moore R, et al., Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues. BMC Dev Biol. 2013;13:39
• All: 1 reference(s)