Hes1^tm2.1Kag
Targeted Allele Detail

Summary

• Symbol: Hes1^tm2.1Kag
• Name: hes family bHLH transcription factor 1; targeted mutation 2.1, Ryoichiro Kageyama
• MGI ID: MGI:5562879
• Synonyms: Venus-Hes1
• Gene: Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
• Alliance: Hes1^tm2.1Kag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203419
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A Venus expression cassette was inserted in frame in the 5' region, a loxP site was inserted 3' of the Venus expression cassette and a floxed inverted pgk-neo cassette was inserted in the 3' region of the gene. Cre mediated recombination removed the neo cassette leaving most of the exons floxed. Reporter expression is similar to endogenous gene expression. (J:203419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hes1 Mutation: 23 strains or lines available

References

• Original: J:203419 Imayoshi I, et al., Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science. 2013 Dec 6;342(6163):1203-8
• All: 3 reference(s)