Yy1^tm3.1Yshi
Targeted Allele Detail

Summary

• Symbol: Yy1^tm3.1Yshi
• Name: YY1 transcription factor; targeted mutation 3.1, Yang Shi
• MGI ID: MGI:5562922
• Synonyms: Yy1^ihCd2
• Gene: Yy1 Location: Chr12:108758899-108786074 bp, + strand Genetic Position: Chr12, 59.58 cM
• Alliance: Yy1^tm3.1Yshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208226
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted downstream of the stop codon a preSc cleavage site, FLAG-tag, V5-tag, TEV cleavage site and biotin acceptor sequence, FRT site, IRES, human Cdc2 reporter gene, FRT site, and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:208226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yy1 Mutation: 35 strains or lines available

References

• Original: J:208226 Medvedovic J, et al., Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 2013 Aug 22;39(2):229-44
• All: 1 reference(s)