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Del(8Defb1-Defb13)1Jrdo
Targeted Allele Detail
Summary
Symbol: Del(8Defb1-Defb13)1Jrdo
Name: deletion, Chr 8, Julia R Dorin 1
MGI ID: MGI:5562924
Synonyms: Defbdelta9
Gene: Del(8Defb1-Defb13)1Jrdo  Location: unknown  Genetic Position: Chr8, Syntenic
Increased number of detached heads in the cauda epididymal sperm from Del(8Defb1-Defb13)1Jrdo/Del(8Defb1-Defb13)1Jrdo mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204187
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(8Defb1-Defb13)1Jrdo involves 15 genes/genome features (Scc8, Pnhdlc3, Eae36 ...) View all
 
Mutation detailsA MICER clone carrying exons 1 and 2 of the HPRT gene, a neo cassette, a loxP site and Tyrosinase gene was inserted downstream of Defb13 and a MICER clone carrying exons 3-9 of the HPRT gene, a puro cassette, a loxP site and Agouti gene was inserted upstream of Defb1. Cre mediated recombination removed a 175 kb region encompassing 9 beta defensin genes (Defb1, Defb50, Defb2, Defb10, Defb9, Defb11, Defb15, Defb35 and Defb13) and reconstituting an intact Hprt gene. RT-PCR analysis confirmed the absence of expression of the nine deleted genes in homozygous mice. (J:204187)
Generation of the Del(8Defb1-Defb13)1Jrdo deletion
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(8Defb1-Defb13)1Jrdo Mutation:  0 strains or lines available
References
Original:  J:204187 Zhou YS, et al., Partial deletion of chromosome 8 beta-defensin cluster confers sperm dysfunction and infertility in male mice. PLoS Genet. 2013 Oct;9(10):e1003826
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory