Del(8Defb1-Defb13)1Jrdo
Targeted Allele Detail
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Symbol: |
Del(8Defb1-Defb13)1Jrdo |
Name: |
deletion, Chr 8, Julia R Dorin 1 |
MGI ID: |
MGI:5562924 |
Synonyms: |
Defbdelta9 |
Gene: |
Del(8Defb1-Defb13)1Jrdo Location: unknown Genetic Position: Chr8, Syntenic
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Increased number of detached heads in the cauda epididymal sperm from Del(8Defb1-Defb13)1Jrdo/Del(8Defb1-Defb13)1Jrdo mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:204187
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intergenic deletion, Intragenic deletion
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Del(8Defb1-Defb13)1Jrdo involves 15 genes/genome features (Scc8, Pnhdlc3, Eae36 ...)
View all
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Mutation details: A MICER clone carrying exons 1 and 2 of the HPRT gene, a neo cassette, a loxP site and Tyrosinase gene was inserted downstream of Defb13 and a MICER clone carrying exons 3-9 of the HPRT gene, a puro cassette, a loxP site and Agouti gene was inserted upstream of Defb1. Cre mediated recombination removed a 175 kb region encompassing 9 beta defensin genes (Defb1, Defb50, Defb2, Defb10, Defb9, Defb11, Defb15, Defb35 and Defb13) and reconstituting an intact Hprt gene. RT-PCR analysis confirmed the absence of expression of the nine deleted genes in homozygous mice.
(J:204187)
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Generation of the Del(8Defb1-Defb13)1Jrdo deletion |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(8Defb1-Defb13)1Jrdo Mutation: |
0 strains or lines available
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Original: |
J:204187 Zhou YS, et al., Partial deletion of chromosome 8 beta-defensin cluster confers sperm dysfunction and infertility in male mice. PLoS Genet. 2013 Oct;9(10):e1003826 |
All: |
1 reference(s) |
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