Pomt2^tm1Sstr
Targeted Allele Detail

Summary

• Symbol: Pomt2^tm1Sstr
• Name: protein-O-mannosyltransferase 2; targeted mutation 1, Sabine Strahl
• MGI ID: MGI:5563037
• Gene: Pomt2 Location: Chr12:87153635-87194742 bp, - strand Genetic Position: Chr12, 41.3 cM
• Alliance: Pomt2^tm1Sstr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205502
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including parts of exons 2 and 3 was replaced a neo cassette via homologous recombination. This results in a frameshift mutation after amino acid T100 and a premature stop after 4 additional amino acids. (J:205502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pomt2 Mutation: 38 strains or lines available

References

• Original: J:205502 Lommel M, et al., Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21024-9
• All: 1 reference(s)