Itch^tm1.1Alta
Targeted Allele Detail

Summary

• Symbol: Itch^tm1.1Alta
• Name: itchy, E3 ubiquitin protein ligase; targeted mutation 1.1, Alexander Tarakhovsky
• MGI ID: MGI:5563090
• Synonyms: Itch^fl
• Gene: Itch Location: Chr2:154975429-155068775 bp, + strand Genetic Position: Chr2, 76.94 cM
• Alliance: Itch^tm1.1Alta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204685
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the sixth exon encoding the hect-domain. A floxed neomycin resistance cassette was inserted downstream of this exon. Cre-mediated recombination removed the selection cassette and left the exon floxed. (J:204685)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itch Mutation: 92 strains or lines available

References

• Original: J:204685 Jin HS, et al., Itch expression by Treg cells controls Th2 inflammatory responses. J Clin Invest. 2013 Nov 1;123(11):4923-34
• All: 3 reference(s)