Stx1a^tm1Migar
Targeted Allele Detail

Summary

• Symbol: Stx1a^tm1Migar
• Name: syntaxin 1A (brain); targeted mutation 1, Michihiro Igarashi
• MGI ID: MGI:5563140
• Synonyms: syntaxin-1A (R151G)
• Gene: Stx1a Location: Chr5:135052336-135079954 bp, + strand Genetic Position: Chr5, 74.95 cM
• Alliance: Stx1a^tm1Migar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204968
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 6 was replaced with one in which an A to G mutation results in the amino acid substitution of arginine with glycine at position 151 (p.R151G). This missense mutation interfers with the interaction between the peptide encoded by this allele and the Camk2 peptide. An FRT site flanked neomycin resistance gene cassette was inserted into intron 7. (J:204968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx1a Mutation: 26 strains or lines available

References

• Original: J:204968 Watanabe Y, et al., Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity. J Biol Chem. 2013 Nov 29;288(48):34906-19
• All: 1 reference(s)