Cd72^c
Allele Detail

Summary

• Symbol: Cd72^c
• Name: CD72 antigen; c haplotype
• MGI ID: MGI:5563235
• Gene: Cd72 Location: Chr4:43447724-43454708 bp, - strand Genetic Position: Chr4, 23.04 cM
• Alliance: Cd72^c page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Not Applicable
• Mutation: Not Applicable
• Mutation details: This serological allele is recognized by epitope 3 (J:8236). Sequence differences between the haplotypes (a, b and c) largely result in amino acid variation in the extracellular domains. The c haplotype contains a 7 amino acid deletion in the C-type lectin-like domain. However, the amino acid sequence of the transmembrane domain and cytoplasmic region is identical to the other hapotype alleles (a, b and d). This allele was identified in the strains AKR, MRL and SJL. (J:1507, J:23623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd72 Mutation: 30 strains or lines available

Notes

The Cd72^c haplotype is a modifier of Fas^lpr-induced autoimmune disease. J:204782

References

• Original: J:1507 Robinson WH, et al., Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. J Immunol. 1992 Aug 1;149(3):880-6
• All: 6 reference(s)