Nras^tm2.1Tyj
Targeted Allele Detail

Summary

• Symbol: Nras^tm2.1Tyj
• Name: neuroblastoma ras oncogene; targeted mutation 2.1, Tyler Jacks
• MGI ID: MGI:5563361
• Synonyms: Nras^2lox2
• Gene: Nras Location: Chr3:102965643-102975230 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Nras^tm2.1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204263
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:204263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nras Mutation: 44 strains or lines available

References

• Original: J:204263 Xu J, et al., Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov. 2013 Sep;3(9):993-1001
• All: 1 reference(s)