Dhfr^orana
Chemically induced Allele Detail

Summary

• Symbol: Dhfr^orana
• Name: dihydrofolate reductase; orana
• MGI ID: MGI:5563476
• Synonyms: Dhfr^ora, Dhfr^Thr136Ala, ENU15:B10:025
• Gene: Dhfr Location: Chr13:92491291-92525561 bp, + strand Genetic Position: Chr13, 47.64 cM
• Alliance: Dhfr^orana page

Mutation origin

• Strain of Origin: C57BL/6JAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A single base substitution (A to G) of base pair 885 in exon 5 (ENSMUSE00000120178) was detected. This mutation results in an ACA (Thr)-to-GCA (Ala) change of amino acid 136. DHFR protein was essentially undetectable in homozygous embryos. (J:104190)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhfr Mutation: 18 strains or lines available

References

• Original: J:104190 The Australian Phenomics Facility at The Australian National University, Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University. MGI Direct Data Submission. 2006-2014
• All: 2 reference(s)