Hmgb1^tm1.2Ttg
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1.2Ttg
• Name: high mobility group box 1; targeted mutation 1.2, Tadatsugu Taniguchi
• MGI ID: MGI:5563524
• Synonyms: Hmgb1^-
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1.2Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205499
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-neo-loxP cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and exons 2-4. (J:205499)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Hmgb1^tm1.1Ttg/Hmgb1^tm1.2Ttg Tg(CAG-cre)13Miya/0	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
mortality/aging	√
neonatal lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 17 strains or lines available

References

• Original: J:205499 Yanai H, et al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20699-704
• All: 1 reference(s)