Hottip^tm1Vlcg
Targeted Allele Detail

Summary

• Symbol: Hottip^tm1Vlcg
• Name: Hoxa distal transcript antisense RNA; targeted mutation 1, Velocigene
• MGI ID: MGI:5563534
• Gene: Hottip Location: Chr6:52239760-52244588 bp, + strand Genetic Position: Chr6, 25.41 cM
• Alliance: Hottip^tm1Vlcg page

Hindlimb clasping posture in MGI:5790441/MGI:5790441 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204277
• Parent Cell Line: VGF1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination replaced the entire 4.8 kb gene with a lacZ reporter cassette (including Kozak sequence and ATG start codon) and a loxP site flanked neomycin resistance gene cassette. (J:204277)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hottip Mutation: 1 strain or line available

References

• Original: J:204277 Sauvageau M, et al., Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2013;2(0):e01749
• All: 2 reference(s)