Akt1^tm1Zzy
Targeted Allele Detail

Summary

• Symbol: Akt1^tm1Zzy
• Name: thymoma viral proto-oncogene 1; targeted mutation 1, Zhongzhou Yang
• MGI ID: MGI:5563541
• Synonyms: Akt1^f, Akt1^F, Akt1^fl, Akt1^flox
• Gene: Akt1 Location: Chr12:112620260-112641266 bp, - strand Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
• Alliance: Akt1^tm1Zzy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 11. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 3-11 floxed. (J:326580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1 Mutation: 34 strains or lines available

References

• Original: J:206783 Di R, et al., S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. Biochem J. 2012 Jan 1;441(1):199-207
• All: 8 reference(s)