Tg(SV40-KLK7)1010Teg
Transgene Detail

Summary

• Symbol: Tg(SV40-KLK7)1010Teg
• Name: transgene insertion 1010, Torbjorn Egelrud
• MGI ID: MGI:5563691
• Synonyms: Tg1010^SV40e-hscce
• Transgene: Tg(SV40-KLK7)1010Teg Location: unknown
• Alliance: Tg(SV40-KLK7)1010Teg page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SV40-KLK7)1010Teg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KLK7 (5650)

  Klk7	(MGI:1346336)

• Mutation details: The human KLK7 cDNA is under the control of the SV40 early enhancer and promoter elements. Three lines were established; 103, 107, and 1010, however only this line shows a skin phenotype. Enzyme-linked immunosorbent assay confirmed protein expression in skin, intestines, and lung and immunoblotting indicates that proteolytically active enzyme is produced. (J:75714)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:75714 Hansson L, et al., Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. J Invest Dermatol. 2002 Mar;118(3):444-9
• All: 3 reference(s)