Man2c1^tm1.1Tbec
Targeted Allele Detail

Summary

• Symbol: Man2c1^tm1.1Tbec
• Name: mannosidase, alpha, class 2C, member 1; targeted mutation 1.1, Tommaso Beccari
• MGI ID: MGI:5564742
• Gene: Man2c1 Location: Chr9:57037953-57049497 bp, + strand Genetic Position: Chr9, 30.89 cM, cytoband C
• Alliance: Man2c1^tm1.1Tbec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205550
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 7 to disrupt gene expression. Western blot analysis showed absence of expression in liver and kidney extracts. (J:205550)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Man2c1 Mutation: 50 strains or lines available

References

• Original: J:205550 Paciotti S, et al., Accumulation of free oligosaccharides and tissue damage in cytosolic alpha-mannosidase (Man2c1)-deficient mice. J Biol Chem. 2014 Apr 4;289(14):9611-22
• All: 1 reference(s)