Prdm16^tm1.1Brsp
Targeted Allele Detail

Summary

• Symbol: Prdm16^tm1.1Brsp
• Name: PR domain containing 16; targeted mutation 1.1, Bruce M Spiegelman
• MGI ID: MGI:5564782
• Synonyms: Prdm16^lox
• Gene: Prdm16 Location: Chr4:154400582-154721330 bp, - strand Genetic Position: Chr4, 83.96 cM, cytoband E2
• Alliance: Prdm16^tm1.1Brsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208683
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of exon 9 followed by a frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 9. (J:208683)

Disease models

Expression

In Mice Carrying this Mutation:	8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm16 Mutation: 73 strains or lines available

References

• Original: J:208683 Cohen P, et al., Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16;156(1-2):304-16
• All: 34 reference(s)