Tg(TPO-cre/ERT2)1139Tyj
Transgene Detail

Summary

• Symbol: Tg(TPO-cre/ERT2)1139Tyj
• Name: transgene insertion 1139, Tyler Jacks
• MGI ID: MGI:5565332
• Synonyms: TPOCreER
• Transgene: Tg(TPO-cre/ERT2)1139Tyj Location: unknown
• Alliance: Tg(TPO-cre/ERT2)1139Tyj page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(TPO-cre/ERT2)1139Tyj expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  TPO (7173)

  Tpo	(MGI:98813)

• Mutation details: A construct with the human thyroid peroxidase promoter (TPO) and an inducible cre/estrogen receptor ligand-binding domain fusion (cre/ERT2) was used to generate transgenic founders. Two founders were obtained and one (#1139) was used for further analyses. (J:208854)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	TPO (human) Summary of all recombinase alleles driven by TPO. Alliance human TPO gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(TPO-cre/ERT2)1139Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:208854 McFadden DG, et al., p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1600-9
• All: 3 reference(s)