Grp^tm1Jfb
Targeted Allele Detail

Summary

• Symbol: Grp^tm1Jfb
• Name: gastrin releasing peptide; targeted mutation 1, James F Battey
• MGI ID: MGI:5565455
• Gene: Grp Location: Chr18:66005891-66019667 bp, + strand Genetic Position: Chr18, 38.98 cM
• Alliance: Grp^tm1Jfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205122
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. Immunostaining analysis confirmed the absence of expression in dorsal root ganglion and spinal cord neurons. (J:205122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grp Mutation: 30 strains or lines available

References

• Original: J:205122 Zhao ZQ, et al., Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest. 2013 Nov 1;123(11):4769-80
• All: 6 reference(s)