Tg(Pbsn-FGFR1*K656E)#Wmck
Transgene Detail

Summary

• Symbol: Tg(Pbsn-FGFR1*K656E)#Wmck
• Name: transgene insertion, Wallace L McKeehan
• MGI ID: MGI:5565702
• Synonyms: PB-caFGFR1
• Transgene: Tg(Pbsn-FGFR1*K656E)#Wmck Location: unknown
• Alliance: Tg(Pbsn-FGFR1*K656E)#Wmck page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human FGFR1 with a substitution of lysine 656 in the auto-inhibition loop of the tyrosine kinase domain with glutamic acid is under the control of the prostate specific rat probasin promoter. This mutation alters the conformation of the auto inhibition loop in the tyrosine kinase domain that exposes the catalytic site of the kinase to substrates without external activation of the FGFR complex thus creating a constitutive active FGFR1. Three lines were established. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:87519)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87519 Wang F, et al., Chronic activity of ectopic type 1 fibroblast growth factor receptor tyrosine kinase in prostate epithelium results in hyperplasia accompanied by intraepithelial neoplasia. Prostate. 2004 Jan 1;58(1):1-12
• All: 2 reference(s)