Dicer1^em2Psv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dicer1^em2Psv
• Name: dicer 1, ribonuclease type III; endonuclease-mediated mutation 2, Petr Svoboda
• MGI ID: MGI:5566697
• Synonyms: delMT⁴⁶³, deltaMT
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^em2Psv page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: The MT-C retrotransposon element in intron 6 was deleted via TALEN mediated recombination. This abolishes expression of an oocyte specific isoform (Dicer1^O) without altering expression of the somatic isoform (Dicer1^S). The deletion is located at chr12:104,727,100-104,727,562 (m38/mm10). (J:203415)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:203415 Flemr M, et al., A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell. 2013 Nov 7;155(4):807-16
• All: 1 reference(s)