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Dicer1em3Psv
Endonuclease-mediated Allele Detail
Summary
Symbol: Dicer1em3Psv
Name: dicer 1, ribonuclease type III; endonuclease-mediated mutation 3, Petr Svoboda
MGI ID: MGI:5566698
Synonyms: delMT667, deltaMT
Gene: Dicer1  Location: Chr12:104654001-104718211 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Alliance: Dicer1em3Psv page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Endonuclease-mediated (Modified isoform(s))
Mutation:    Intragenic deletion
 
Mutation detailsThe MT-C retrotransposon element in intron 6 was deleted via TALEN mediated recombination. This abolishes expression of an oocyte specific isoform (Dicer1O) without altering expression of the somatic isoform (Dicer1S). The deletion is located at chr12:104,727,110-104,727,776 (m38/mm10). (J:203415)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  96 strains or lines available
References
Original:  J:203415 Flemr M, et al., A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell. 2013 Nov 7;155(4):807-16
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory