Crtc2^tm1Mmy
Targeted Allele Detail

Summary

• Symbol: Crtc2^tm1Mmy
• Name: CREB regulated transcription coactivator 2; targeted mutation 1, Marc R Montminy
• MGI ID: MGI:5566704
• Gene: Crtc2 Location: Chr3:90161475-90171432 bp, + strand Genetic Position: Chr3, 39.21 cM, cytoband F2
• Alliance: Crtc2^tm1Mmy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157556
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a PGK-neo selection cassette. This removed sequences encoding the N-terminal CREB binding domain. (J:157556)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crtc2 Mutation: 27 strains or lines available

References

• Original: J:157556 Wang Y, et al., Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3087-92
• All: 9 reference(s)