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Aicdatm1.1Fwa
Targeted Allele Detail
Summary
Symbol: Aicdatm1.1Fwa
Name: activation-induced cytidine deaminase; targeted mutation 1.1, Frederick W Alt
MGI ID: MGI:5566773
Synonyms: AIDS38A
Gene: Aicda  Location: Chr6:122530768-122541139 bp, + strand  Genetic Position: Chr6, 57.65 cM, cytoband F2
Alliance: Aicdatm1.1Fwa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209271
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 2 was replaced with a modified exon 2 in which the nucleotide substitutions (AGT to GCT) result in the amino acid substitution of alanine for serine at position 38 (S38A). This mutation is predicted not to interact with endogenous replication protein A. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 2. (J:209271)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aicda Mutation:  57 strains or lines available
References
Original:  J:209271 Cheng HL, et al., Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2717-22
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory