Hsd11b1^tm1.1Awhi
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1.1Awhi
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1.1, Anne White
• MGI ID: MGI:5566777
• Gene: Hsd11b1 Location: Chr1:192903917-192946345 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1.1Awhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207713
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites. Cre-mediated recombination removed exon 2 and the neomycin resistance cassette. Enzymatic activity is below detection limits. (J:207713)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 28 strains or lines available

References

• Original: J:207713 Harno E, et al., 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors still improve metabolic phenotype in male 11beta-HSD1 knockout mice suggesting off-target mechanisms. Endocrinology. 2013 Dec;154(12):4580-93
• All: 1 reference(s)