Serpina1a^tm1Amgh
Targeted Allele Detail

Summary

• Symbol: Serpina1a^tm1Amgh
• Name: serine (or cysteine) peptidase inhibitor, clade A, member 1A; targeted mutation 1, A McGarry Houghton
• MGI ID: MGI:5566806
• Gene: Serpina1a Location: Chr12:103819848-103829821 bp, - strand Genetic Position: Chr12, 52.98 cM
• Alliance: Serpina1a^tm1Amgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208746
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• A GFP gene and floxed neomycin resistance cassette were inserted into exon 2. (J:208746)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpina1a Mutation: 21 strains or lines available

References

• Original: J:208746 Wang D, et al., Deletion of Serpina1a, a murine alpha1-antitrypsin ortholog, results in embryonic lethality. Exp Lung Res. 2011 Jun;37(5):291-300
• All: 1 reference(s)