Gcgr^tm2.1Mjch
Targeted Allele Detail

Summary

• Symbol: Gcgr^tm2.1Mjch
• Name: glucagon receptor; targeted mutation 2.1, M J Charron
• MGI ID: MGI:5566811
• Synonyms: Gcgr^Flox
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^tm2.1Mjch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette and left exons 6 through 12 floxed. (J:208604)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 8 strains or lines available

References

• Original: J:208604 Longuet C, et al., Liver-specific disruption of the murine glucagon receptor produces alpha-cell hyperplasia: evidence for a circulating alpha-cell growth factor. Diabetes. 2013 Apr;62(4):1196-205
• All: 14 reference(s)