Zic2^em5Bend
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zic2^em5Bend
• Name: zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 5, Ben Davies
• MGI ID: MGI:5566856
• Synonyms: C3H-19, Zic2^A19
• Gene: Zic2 Location: Chr14:122712847-122717264 bp, + strand Genetic Position: Chr14, 65.97 cM
• Alliance: Zic2^em5Bend page

Mutation origin

• Strain of Origin: C3H/HeH

Mutation description

Allele Type: Endonuclease-mediated (Null/knockout) Mutations: Intragenic deletion, Single point mutation Mutation details: TALEN mediated recombination introduced a 12 bp deletion and an A to C mutation resulting in a 4 amino acid deletion (Tyr 401 - Ser 405) and the insertion of an Arginine (p.Tyr401_Ser405delinsArg). (J:199882)

TALEN mediated recombination scheme used to generate the Zic2^em1Bend, Zic2^em2Bend, Zic2^em3Bend, Zic2^em4Bend and Zic2^em5Bend alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zic2 Mutation: 41 strains or lines available

References

• Original: J:199882 Davies B, et al., Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes. PLoS One. 2013;8(3):e60216
• All: 2 reference(s)