Tg(ACTA1*D286G)#Kjno
Transgene Detail

Summary

• Symbol: Tg(ACTA1*D286G)#Kjno
• Name: transgene insertion, Kristen J Nowak
• MGI ID: MGI:5566909
• Synonyms: Tg(ACTA1)^D286G
• Transgene: Tg(ACTA1*D286G)#Kjno Location: unknown
• Alliance: Tg(ACTA1*D286G)#Kjno page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1*D286G)#Kjno expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: The human cDNA with the D286G mutation is under the control of a 2.2 kb fragment of the human skeletal muscle alpha-actin promoter and the 157 bp slow human troponin I enhancer. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:209273)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:209273 Ravenscroft G, et al., Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies. Brain. 2011 Apr;134(Pt 4):1101-15
• All: 5 reference(s)