Tg(CAG-A4GALT)#Sais
Transgene Detail

Summary

• Symbol: Tg(CAG-A4GALT)#Sais
• Name: transgene insertion, Satoshi Ishii
• MGI ID: MGI:5566993
• Synonyms: Tg(CAG-A4GALT), TgG3s
• Transgene: Tg(CAG-A4GALT)#Sais Location: unknown
• Alliance: Tg(CAG-A4GALT)#Sais page

Transgene origin

• Strain of Origin: C57BL/6JJms

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-A4GALT)#Sais expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  A4GALT (53947)

  A4galt

  (MGI:3512453)

• Mutation details: This transgene consists of the human alpha 1,4-galactosyltransferase cDNA driven by the CAG promoter (from expression vector expression vector pCXN2). RT-PCR confirmed expression in heart, kidney, liver, spleen, small intestine, brain, lungs and muscle. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:209274)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:209274 Shiozuka C, et al., Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem. 2011 Feb;149(2):161-70
• All: 5 reference(s)