Hprt1^{tm1(Ins2-HBEGF)Herr}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Ins2-HBEGF)Herr}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Pedro Luis Herrera
• MGI ID: MGI:5567081
• Synonyms: RIP-DTR
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Ins2-HBEGF)Herr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159291
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(Ins2-HBEGF)Herr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A targeting vector introduced the human cDNA encoding the diphtheria toxin receptor with an intron and polyadenylation sequence from the rabbit beta-globin gene driven by the rat promoter in beta cells. (J:159291)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:159291 Thorel F, et al., Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010 Apr 22;464(7292):1149-54
• All: 14 reference(s)