Shox2^{tm1.1(cre)Oki}
Targeted Allele Detail

Summary

• Symbol: Shox2^{tm1.1(cre)Oki}
• Name: SHOX homeobox 2; targeted mutation 1.1, Ole Kiehn
• MGI ID: MGI:5567920
• Synonyms: Shox2::Cre
• Gene: Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
• Alliance: Shox2^{tm1.1(cre)Oki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Shox2^{tm1.1(cre)Oki} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Shox2 (MGI:1201673)

• Mutation details: Homologous recombination in ES cells inserted an IRES-nlscre and frt-flanked PGK-neo cassette after the stop codon of the Shox2 coding sequence. The neo was removed by crossing to FLPeR deleter animals. (J:209344)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shox2 (mouse) Summary of all recombinase alleles driven by Shox2. Alliance mouse Shox2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shox2 Mutation: 20 strains or lines available

References

• Original: J:209344 Dougherty KJ, et al., Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons. Neuron. 2013 Nov 20;80(4):920-33
• All: 8 reference(s)