Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ursula Zimber-Strobl |
MGI ID: |
MGI:5567929 |
Synonyms: |
LMP1/CD40flSTOP |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs page
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Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice develop mono- and oligoclonal lymphomas
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:137122
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
BALB/c
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Allele Type: |
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Targeted (Conditional ready, Constitutively active, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CD40 (958) |
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Mutation details: The targeting construct introduced into the locus a floxed neomycin resistance/stop cassette and a fusion of the EBV B95-8 strain Lmp1 coding sequence encoding amino acids 1-190 and the human cDNA encoding amino acids 223-280. This fusion generates a constitutively active receptor that is only expressed after cre-mediated removal of the stop cassette.
(J:137122)
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Generation of the Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
985 strains or lines available
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Original: |
J:137122 Homig-Holzel C, et al., Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med. 2008 Jun 9;205(6):1317-29 |
All: |
5 reference(s) |
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