Klf3^m1Cmhd
Chemically induced Allele Detail

Summary

• Symbol: Klf3^m1Cmhd
• Name: Kruppel-like transcription factor 3 (basic); mutation 1, Centre for Modeling Human Disease
• MGI ID: MGI:5567987
• Synonyms: Klf3^H275R
• Gene: Klf3 Location: Chr5:64960864-64990246 bp, + strand Genetic Position: Chr5, 33.49 cM
• Alliance: Klf3^m1Cmhd page

Aortic valvular stenosis in Klf3^m1Cmhd/Klf3⁺ mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) (Dominant negative) Mutation: Single point mutation Mutation details: ENU mutagenesis induced a G to A point mutation in exon 5 that results in the amino acid substitution of arginine for histidine at position 275 (H275R). The protein product functions as a dominant negative. (J:206507) Inheritance: Dominant

Schematic of the location of the point mutation in the Klf3^m1Cmhd allele

Expression

In Mice Carrying this Mutation:	15 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf3 Mutation: 80 strains or lines available

References

• Original: J:206507 Kelsey L, et al., ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013;9(7):e1003612
• All: 1 reference(s)