Npr2^{tm2.1(cre/ERT2)Fgr}
Targeted Allele Detail

Summary

• Symbol: Npr2^{tm2.1(cre/ERT2)Fgr}
• Name: natriuretic peptide receptor 2; targeted mutation 2.1, Fritz G Rathjen
• MGI ID: MGI:5567995
• Synonyms: Npr2-CreER^T2
• Gene: Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Npr2^{tm2.1(cre/ERT2)Fgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205571
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Npr2^{tm2.1(cre/ERT2)Fgr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npr2 (MGI:97372)

• Mutation details: A targeting construct was used to replace exon 1 of the Npr2 gene with the sequence for a tamoxifen- inducible cre recombinase (cre/ERT2) followed by a polyadenylation signal and an frt-flanked neo selection marker, by homologous recombination in ES cells. The neo marker was deleted by crossbreeding with Flp-expressing mice. (J:205571)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npr2 (mouse) Summary of all recombinase alleles driven by Npr2. Alliance mouse Npr2 gene page

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr2 Mutation: 63 strains or lines available

References

• Original: J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47
• All: 4 reference(s)