Fbxw11^tm1Ybn
Targeted Allele Detail

Summary

• Symbol: Fbxw11^tm1Ybn
• Name: F-box and WD-40 domain protein 11; targeted mutation 1, Yinon Ben-Neriah
• MGI ID: MGI:5568086
• Synonyms: beta-TrCP2^f
• Gene: Fbxw11 Location: Chr11:32592724-32696816 bp, + strand Genetic Position: Chr11, 19.02 cM
• Alliance: Fbxw11^tm1Ybn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206654
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP-flanked neomycin cassette and a third loxP site was used to flank exon 4. (J:206654)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw11 Mutation: 72 strains or lines available

References

• Original: J:206654 Kanarek N, et al., Critical role for IL-1beta in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11
• All: 1 reference(s)