Crbn^tm1Csp
Targeted Allele Detail

Summary

• Symbol: Crbn^tm1Csp
• Name: cereblon; targeted mutation 1, Chul-Seung Park
• MGI ID: MGI:5568118
• Gene: Crbn Location: Chr6:106757162-106777038 bp, - strand Genetic Position: Chr6, 49.24 cM, cytoband E2
• Alliance: Crbn^tm1Csp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1. Western blot analysis confirmed the absence of protein expressopm in the liver, skeletal muscle and white adipose tissue. (J:208570)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crbn Mutation: 33 strains or lines available

References

• Original: J:208570 Lee KM, et al., Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice. Diabetes. 2013 Jun;62(6):1855-64
• All: 13 reference(s)