Lrrk1^tm1.1Smo
Targeted Allele Detail

Summary

• Symbol: Lrrk1^tm1.1Smo
• Name: leucine-rich repeat kinase 1; targeted mutation 1.1, Subburaman Mohan
• MGI ID: MGI:5568128
• Gene: Lrrk1 Location: Chr7:65908493-66038089 bp, - strand Genetic Position: Chr7, 35.57 cM
• Alliance: Lrrk1^tm1.1Smo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208677
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 16 through 19 (numbered according to accession NM_146191.3). Cre-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in osteoclasts and bone marrow stromal cells. (J:208677)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk1 Mutation: 78 strains or lines available

References

• Original: J:208677 Xing W, et al., Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. J Bone Miner Res. 2013 Sep;28(9):1962-74
• All: 2 reference(s)