Tg(Gata1-icre)1Jtp
Transgene Detail

Summary

• Symbol: Tg(Gata1-icre)1Jtp
• Name: transgene insertion 1, Josef T Prchal
• MGI ID: MGI:5568218
• Synonyms: Gata-1-HRD-iCre
• Transgene: Tg(Gata1-icre)1Jtp Location: unknown
• Alliance: Tg(Gata1-icre)1Jtp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gata1-icre)1Jtp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Gata1

• Mutation details: A construct was generated by inserting the icre (improved cre) cDNA between the promoter region and polyA site in the IE3.9intpolyAA construct (containg the Gata1-HRD promoter (HRD; hematopoietic regulatory domain)). The transgenic vector was verified by sequencing, linearized and used for pronuclear injection. Three transgenic founders were identified from 16 chimeras, and cre activity was assessed in progeny of crossed to ROSA26 reporter animals. Reporter activation was detected only in bone marrow cells (in early erythroid progenitors) and not in any other organ or tissue examined. The line with greatest cre activity was selected for further analyses. (J:209268)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gata1 (species not specified) Summary of all recombinase alleles driven by Gata1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:209268 Yoon D, et al., Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific. Blood Cells Mol Dis. 2008 May-Jun;40(3):381-7
• All: 1 reference(s)