Insig1^tm1.1Aztc
Targeted Allele Detail

Summary

• Symbol: Insig1^tm1.1Aztc
• Name: insulin induced gene 1; targeted mutation 1.1, Astrazeneca Transgenic Center
• MGI ID: MGI:5568496
• Gene: Insig1 Location: Chr5:28276410-28283660 bp, + strand Genetic Position: Chr5, 13.94 cM
• Alliance: Insig1^tm1.1Aztc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette and exons 2 through 4. (J:208931)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insig1 Mutation: 17 strains or lines available

References

• Original: J:208931 Carobbio S, et al., Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes. 2013 Nov;62(11):3697-708
• All: 2 reference(s)