Cd79a^{tm3(cre/ERT2)Reth}
Targeted Allele Detail

Summary

• Symbol: Cd79a^{tm3(cre/ERT2)Reth}
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 3, Michael Reth
• MGI ID: MGI:5568505
• Synonyms: mb1-CreER^T2, MCE
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^{tm3(cre/ERT2)Reth} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194830
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cd79a^{tm3(cre/ERT2)Reth} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd79a (MGI:101774)

• A cDNA encoding the tamoxifen-inducible cre recombinase (cre/ERT2) was knocked into exon 2. (J:217519)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd79a (mouse) Summary of all recombinase alleles driven by Cd79a. Alliance mouse Cd79a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 24 strains or lines available

References

• Original: J:194830 Schweighoffer E, et al., The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway. Immunity. 2013 Mar 21;38(3):475-88
• All: 11 reference(s)