Hprt1^{tm4(Tek-IGF1R)Geno}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm4(Tek-IGF1R)Geno}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, Genoway
• MGI ID: MGI:5568544
• Synonyms: hIGFREO
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm4(Tek-IGF1R)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208523
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm4(Tek-IGF1R)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1R (3480)

  Igf1r

  (MGI:96433)

• Mutation details: The targeting vector reconstituted the gene and inserted into the locus the promoter driving endothelium-specific expression of the human cDNA with a polyadenylation sequence followed by a core enhancer. (J:208523)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:208523 Imrie H, et al., Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes. 2012 Sep;61(9):2359-68
• All: 2 reference(s)